发明名称 |
THERAPEUTIC ANTI-HIV OLIGONUCLEOTIDE AND PHARMACEUTICAL |
摘要 |
Disclosed are oligonucleotides having nucleotide sequences that hybridize to at least nucleotides 324 to 348 of a conserved (gag) region of the HIV-1 genome. These oligonucleotides have about 25 to 30 nucleotides linked by at least one non-phosphodiester internucleotide linkage which render them resistant to nuclease digestion. Also disclosed are therapeutic formulations containing such oligonucleotides and methods of inhibition HIV-1 proliferation and of treating HIV-1 infection in a mammal. |
申请公布号 |
WO9408004(A1) |
申请公布日期 |
1994.04.14 |
申请号 |
WO1993US09392 |
申请日期 |
1993.10.04 |
申请人 |
HYBRIDON, INC. |
发明人 |
AGRAWAL, SUDHIR;TANG, JIN, YAN |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K48/00;A61P31/12;C07H21/04;C12N;C12N15/113;C12Q1/68;(IPC1-7):C12N15/11 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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