BIOTECHNOLOGICAL METHOD OF PRODUCING BIOTIN

摘要

The invention pertains to DNA fragments and plasmids comprising the bioB, bioF, bioC, bioD and bioA genes responsible for biosynthesis of biotin, or their functionally equivalent genetic variants and mutants from enteric bacteria, wherein the genes are arranged in a transcription unit. The invention also pertains to microorganisms that contain these DNA fragments and plasmids and a method of producing biotin using these microorganisms.