VASOACTIVE PEPTIDE INHIBITION

摘要

Certain known hydroxamic acid derivatives and their salts are useful as inhibitors of the conversion of Big Endothelin to Endothelin by a putative endothelin converting enzyme, and are useful in the management of diseases mediated by overproduction of, or over-responsiveness to, endothelin in mammals. Examples of such compounds are (4-(N-Hydroxyamino)-2R-isobutylsuccinyl)-L-phenylalanine; (4-(N-Hydroxyamino)-2R-isobutylsuccinyl)-4-(oxymethylenecarboxyethyl)-L-phenylalanine-N-methylamide; (4-(N-Hydroxyamino)-2R-isobutylsuccinyl)-4-(oxymethylenecarboxamido)-L-phenylalanine-N-methylamide; and (4-(N-Hydroxyamino)-2R-isopropylsuccinyl)-L-phenylalanine.