CHROMOSOME-SPECIFIC NUCLEIC ACID PROBE FOR FAMILIAL POLYPOSIS COLI.

摘要

PCT No. PCT/GB88/00665 Sec. 371 Date Apr. 12, 1990 Sec. 102(e) Date Apr. 12, 1990 PCT Filed Aug. 11, 1988 PCT Pub. No. WO89/01481 PCT Pub. Date Feb. 23, 1989.A nucleic acid fragment capable of selectively hybridizing with the human chromosome 5 at the chromosomal region 5q20-q23 is disclosed. Also disclosed are probes which include the fragment bearing a detectable level as well as processes for presymptomatic screening for FAP and processes for the pathological classification of colonic tumors and precancerous polyps.