| 摘要 |
PCT No. PCT/US93/08705 Sec. 371 Date Mar. 20, 1995 Sec. 102(e) Date Mar. 20, 1995 PCT Filed Sep. 21, 1993 PCT Pub. No. WO94/06784 PCT Pub. Date Mar. 31, 1994Amides of the formula <IMAGE> wherein: R1 is A and R2 is B; R1 is B and R2 is A; or R1 and R2 are independently selected from the group B; A is phenyl, substituted phenyl, heteroaryl, or substituted heteroaryl; B is cycloalkyl, substituted cycloalkyl, heterocycloalkyl, or substituted heterocycloalkyl; R3 is an alkyl chain of 1 to 25 carbon atoms, branched or straight; an alkenyl chain of 2 to 25 carbon atoms, branched or straight; a substituted alkyl chain; a substituted alkenyl chain; an interrupted alkyl chain; an interrupted alkenyl chain; a substituted interrupted alkyl chain; or a substituted interrupted alkenyl chain; R4 is hydrogen, lower alkyl, phenyl, Q-substituted phenyl, heteroaryl or Q-substituted heteroaryl; R6 and R7 are both H, or R6 and R7 together represent =O; or a pharmaceutically acceptable salt thereof; useful as inhibitors of acyl-coenzyme A:cholesterol acyl transferase and therefore in the treatment of atherosclerosis are disclosed. |
