| 摘要 |
The design, construction, and use of transgenic animals which exhibit features, including neurofibrillary tangles and aluminum sensitivity, is described. The founder transgenic animals of the invention are produced by methods well known in the art, and utilize DNA sequences designed to express all or any part of the human neurofilament subunit genes, NF-L, NF-M, NF-H, in a neural-enriched manner. |
