发明名称 |
Peptide and DNA sequences |
摘要 |
Secretory leader sequences, for use in secreting heterologous polypeptides in yeast, are formed by fusing part of the human serum albumin pre-sequence or part of the Kluyveromyces lactis killer toxin pre-sequence to the Saccharomyces cerevisiae mating factor alpha-1 KEX2 cleavage recognition site. The resulting fusion leader sequences are: (a) H2N-Met-Lys-Trp-Val-Ser-Phe-Ile-Ser-Leu-Leu-Phe-Leu-Phe-Ser-Ser-Ala-Tyr-Ser-Arg-Ser-Leu-Asp-Lys-Arg-COOH or (b) H2N-Met-Asn-Ile-Phe-Tyr-Ile-Phe-Leu-Phe-Leu-Leu-Ser-Phe-Val-Gln-Gly-Ser-Leu-Asp-Lys-Arg-COOH Conservative variations are also encompassed.
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申请公布号 |
US5302697(A) |
申请公布日期 |
1994.04.12 |
申请号 |
US19930067243 |
申请日期 |
1993.05.21 |
申请人 |
DELTA BIOTECHNOLOGY LIMITED |
发明人 |
GOODEY, ANDREW R.;BELFIELD, GRAHAM P.;SLEEP, DARRELL |
分类号 |
C12N15/09;A61K38/00;C07K14/00;C07K14/39;C07K14/76;C07K14/765;C07K19/00;C12N1/19;C12N15/62;C12N15/81;C12P21/02;C12R1/645;C12R1/865;(IPC1-7):A61K37/00;A61K37/02;C07K7/00;C12P21/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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