Aryl-substituted cyclic ether derivatives, their preparation and pharmaceutical compositions containnig them

摘要

The invention concerns a cyclic ether derivative of the formula I wherein Ar<1> is optionally substituted phenyl or naphthyl; A<1> is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo-(3-6C)alkylene; Ar<2> is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms; R<1> and R<2> together form a group of the formula -A<2>-X-A<3>- wherein each of A<2> and A<3> is (1-6C)alkylene and X is oxy, thio, sulphinyl, sulphonyl or imino; and R<3> is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.