| 摘要 |
This invention is directed to methods for preventing the emergence of multidrug resistance in tumor cells during cancer chemotherapy. In particular, it relates to the use of protein kinase inhibitors to prevent the induction of the multidrug resistance (MDR1) gene by chemotherapeutic drugs. MDR1 gene expression, which results in tumor cell resistance to subsequent treatment with certain chemotherapeutic drugs is shown herein to be induced in response to treatment with various cytotoxic agents. Inhibitors of protein kinases are also shown herein to suppress this cellular response. Therefore, protein kinase inhibitors may be useful in the prevention of MDR1 induction by chemotherapeutic drugs in a variety of tumor cells, when administered prior to and/or simultaneous with cytotoxic drug treatment in cancer patients. |
