| 摘要 |
Transdermal polymer dosage units are provided which comprise a backing layer and a reservoir layer. The reservoir layer can have multiple regions which contact the skin during use, optionally may have different pharmaceuticals, may provide variable rate of transdermal absorption, and may provide the pharmaceuticals in the form of microreservoirs or one or more macroreservoirs. The reservoir region can comprise a macroreservoir of one or more pharmaceuticals wherein the reservoir is bounded by a backing layer and a layer of a substantially non-porous permeability-regulating polymer membrane which directly or indirectly contacts the skin during transdermal administration. Also, provided is a process of transdermal administration of pharmaceuticals using the novel dosage units. |
