| 摘要 |
3,4-Dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide- 3-carboxylic acid derivs. of formula (I), their racemates, enantiomers and metal or nitrogen contg. base addn. salts are new. R = H, alkyl, allyl, phenyl, 2- or 3-pyridylalkyl, 2-quinolylalkyl, naphthylalkyl, cycloalkylalkyl, 2H-3-naphtho-(1,8-ca)-isothiazl-2-yl-1,1-dioxide)alkyl, 15,6-dihydro- 1H,4H-1,2,5-thiadiazolo(4,3,2-ij)quinolyl- 2,2-dioxide)alkyl, alk-COR5, alkR6R7, 4-phenyl- piperazinylalkyl (opt. phenyl ring. subsd. by halo, alkyl and.or alkoxy), 10-phenothiazinylalkyl, (10-alkyl-2-phenothiazinyl)alkyl, 3-indolylalkyl, phenylalkyloxy, 1-phenylalkyl-4-piperidyl, 2-thienylalkyl or phenyalkyl (opt. ring substd.); R1 = COOH, alkoxycarbonyl, tetrazolyl, CONH2, CONHalk, CON(alk)2, CONHOH, CON(alk)OH, CONHOR8, CON(alk)OR8 or a gp. convertible in vivo to carboxy; R2-R4 = H, halo, alkyl or alkoxy; R5 = OH, alkoxy, phgenyl or NR9R10; R6 = O, S, N, S, SO2 or Nalk; R7 = alkyl, phenylalkyl, or phenyl opt. substd. by one or more halo; R89 = alkyl or phenylalkyl; R9, R10 = H, alkyl or phenyl; alk = alkyl or alkylene; alkyl, alkoxy or alkylene contain 1-10C.
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