PURIFIED HEMATOPORPHYRIN TRIMERS USEFUL IN PHOTODYNAMIC THERAPY.

摘要

Pure dimer and trimer compounds of hematoporphyrin are prepared and shown to be effective agents in photodynamic therapy. The compounds of the invention are of the formula (1) or (11) (2-A) OMe HCNHMe NMeMeHO MeHNCO2R NMeCO2R+RE wherein each X is independently 1-hydroxyethyl or vinyl and wherein R is H or lower alkyl. The compounds of the invention can be conjugated to targeting substances such as immunoglobulins or to labels.