| 摘要 |
PURPOSE:To obtain the titled substance exhibiting pharmacological activities such as analgesic, anti-inflammatory and antipyretic actions, in high yield, by reacting an alpha-phenylethyl alcohol derivative with carbon dioxide using a specific solvent produced by mixing a hydrocarbon with an oxygen-containing organic compound. CONSTITUTION:The compound of formula II is produced by reacting an alpha-phenyl alcohol derivative of formula I (R is H, alkyl, alkenyl or aryl) with carbon monoxide usually at 30-130 deg.C, preferably at 60-100 deg.C under atmospheric pressure - 100kg/cm<2> in a solvent produced by mixing a hydrocarbon with an oxygen-containing organic compound, in the presence of a catalyst (preferably a transition metal compound) preferably using a rhodium compound as a catalyst and iodine as a cocatalyst. The hydrocarbon used in the above solvent is pentane, benzene, etc., and the oxygen-containing organic compound is acetic acid, etc. The ratio of the solvent components is e.g. preferably 2/98-30/70 by volume in the case of acetic acid/hexane. |
