Therapeutic agents for parkinson's disease.

摘要

Disclosed as therapeutic agents for Parkinson's disease are xanthine derivatives of the formula (I): <CHEM> in which: R<1> and R<2> each represent methyl or ethyl; R<3> represents hydrogen, C1-C6 straight or branched chain alkyl or C2-C6 straight or branched chain alkenyl or alkynyl; R<4> represents C3-C8 cycloalkyl; a -(CH2)n-R<5> group where n is 0 or an integer of from 1 to 4, and R<5> represents phenyl, naphthyl or a heterocyclic group or a substituted phenyl, naphthyl or heterocyclic group containing from 1-4 substituents selected from C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, amino, mono- or di-(C1-C6) alkylamino, trifluoromethyl, benzyloxy, phenyl, phenoxy or C1-C6 alkoxy substituted by hydroxy, C1-C6 alkoxy, halogen, amino, azide, carboxy or (C1-C6 alkoxy)carbonyl; or a <CHEM> group where Y<1> and Y<2> each represent hydrogen, halogen, or C1-C6 straight or branched chain alkyl; and Z represents a <CHEM> group in which R<6> represents hydrogen, hydroxy, C1-C6 straight or branched chain alkyl, C1-C6 straight or branched chain alkoxy, halogen, nitro, or amino, and m represents an integer of from 1 to 4; a phenyl, naphthyl or heterocyclic group or a substituted phenyl, naphthyl or heterocyclic group as defined under R<5>; and X<1> and X<2> each represent O or S; or a pharmaceutically acceptable salt thereof.