| 摘要 |
PURPOSE:To provide the novel compound having an angiotensin II receptor- antagonizing action and using for therapy of hypertension, congestive heat failure, renal failure, glaucoma, etc. CONSTITUTION:A compound of formula I [R<1>, R<2> are H, halogen, lover alkyl, lower alkoxy; X is -CO2R<3> (R<3> is H, lower alkyl), -CN, etc.;-YZ is -CO-NR<4> (R<4> is H, lower alkyl), -CH=CH-, -CH2-CH2-, etc.; R<5> is lover alkyl, cycloalkyl; R<6>, R<7> are H, halogen, etc.], e.g. 2-ethyl-3-[4-(2-methoxycarbonylnaphtho-1-yl) benzyl]-5,7-dimethyl-(3H)-imidazo[4,5-b]pyridine. The compound of formula I is obtained by reacting a compound of formula II (V is Cl, Br, I) with a compound of formula III in the presence of a base (e.g. sodium methoxide) in a solvent (e.g. methanol) at room temperature to 100 deg.C for 1-72hr. |
