发明名称 |
Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations thereof |
摘要 |
Novel substituted pyrazolidinones have been found to exhibit significant binding to cholecystokinin (CCK) receptors and gastrin receptors in the brain and/or peripheral sites such as the pancreas, stomach, and ileum. The pyrazolidinones are CCK and gastrin receptor antagonists and find therapeutic application in the treatment of gastrointestinal disorders, central nervous system disorders and for appetite regulation in warm-blood vertebrates. Pharmaceutical formulations for such indications are described.
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申请公布号 |
US5300514(A) |
申请公布日期 |
1994.04.05 |
申请号 |
US19930033737 |
申请日期 |
1993.03.18 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
BROWN, RAYMOND F.;HOWBERT, J. JEFFRY;LOBB, KAREN L.;NEEL, DAVID A.;REEL, JON K.;GREENWOOD, BEVERLEY |
分类号 |
C07D231/08;C07D233/54;C07D401/04;C07D401/06;C07D403/06;C07D413/04;C07D417/04;(IPC1-7):A61K31/415 |
主分类号 |
C07D231/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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