发明名称 INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS
摘要 This invention provides novel tetrazole intermediates of the formula wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; R2, R3, R5 and R6 each are independently hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy; B is hydrogen, C1-4 alkoxycarbonyl, CH2Y or CH2Z; Y is hydrogen, hydroxyl or X; Z is or ; X is bromo, chloro or iodo; R10 is C1-4 alkyl; and R11 is phenyl which is unsubstituted or substituted by one or two C1-4 alkyl or chloro substituents. and processes thereof which are useful for the preparation of antihypercholesterolemic agents.
申请公布号 CA1328269(C) 申请公布日期 1994.04.05
申请号 CA19880559671 申请日期 1988.02.24
申请人 BRISTOL-MYERS COMPANY 发明人 WRIGHT, JOHN J.;SIT, SING-YUEN;BALASUBRAMANIAN, NEELAKANTAN;BROWN, PETER J.
分类号 A61K31/41;A61P3/06;C02F11/00;C07D257/04;C07D405/06;C07F9/6524 主分类号 A61K31/41
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