摘要 |
Quinoxaline or pyrido pyrazine derivatives of formula (I) wherein R1 is: hydrogen, alkyl, alkoxy, alkylamino, dialkylamino, aminoalkylamino, aminoalkyl(N-alkyl)amino or aminoalkoxy unsubstituted or substituted on the terminal amino group by one or two alkyl groups or a divalent group which forms a saturated heterocyclic ring together with the nitrogen atom to which it is attached, hydroxyalkylamino or haloalkylamino or an N-alkyl derivative thereof, or hydroxyalkoxy or haloalkoxy; a heterocyclic group which is a 1-pyrrolidino, 1-piperidino, 1-morpholino group, unsubstituted or substituted; or a 1-piperazino group which is unsubstituted or substituted substituents in the 2- or 3-position and in the 4-position is unsubstituted or N-substituted by haloalkyl, cycloalkyl, pyridyl or phenyl; R2 is a hydrocarbyl or heterocyclyl aromatic group unsubstituted or substituted; X is -CH= or -N=; and X1 is hydrogen or halogen; and pharmaceutically acceptable salts thereof are useful in the treatment of tumours, and in particular hypoxic tumours. Processes for producing the compounds and pharmaceutical compositions comprising them. |
申请人 |
BRITISH TECHNOLOGY GROUP LIMITED |
发明人 |
ADAMS, GERALD, EDWARD;FIELDEN, EDWARD, MARTIN;NAYLOR, MATTHEW, ALEXANDER;STRATFORD, IAN, JAMES |