发明名称 |
DELIVERY OF PROTEINS BY INTERMEMBRANE TRANSFER FOR PREACCOMMODATION OF XENOGENEIC ORGAN TRANSPLANTS AND OTHER PURPOSES |
摘要 |
GPI-linked proteins are transferred, especially in vivo, from vertebrate carrier cells to cells of a target vertebrate tissue. For example, for purposes of xenogeneic transplantation, cells bearing complement inhibition factor(s) specific for the recipient species, e.g., genetically engineered, red blood cells, are incubated with transplantable cells of a second, discordant donor species until transfer of the factor(s) occurs, The transfer may occur in vivo or in vitro, and the factor-bearing cells may be normal cells of the recipient species, or genetically engineered cells of the donor species which express a gene encoding a complement inhibition factor(s) of the recipient species. The method is particularly useful in modifying pig organs for xenotransplantation into humans. |
申请公布号 |
WO9406903(A1) |
申请公布日期 |
1994.03.31 |
申请号 |
WO1993US08889 |
申请日期 |
1993.09.22 |
申请人 |
DNX BIOTHERAPEUTICS, INC. |
发明人 |
BYRNE, GUERARD, W.;KOOYMAN, DAVID, LEE;LOGAN, JOHN, STEELE |
分类号 |
A01K67/027;A61K35/12;A61K39/00;A61K47/48;C07K14/705;C12N5/06;C12N15/09;C12N15/85;(IPC1-7):C12N5/08 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|