摘要 |
<p>Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria, and other infectious diseases. The compositions contain at least one metazoan protease inhibitor compound containing specific structural elements which bind to the S2 subsite and at least one of the S1 and S1' subsites of the metazoan parasite protease. The protease inhibitors of the present invention generally include at least two homoaromatic or heteroaromatic ring systems, each comprising one to three rings, joined together by suitable linkers. Treatment of a patient infected by a metazoan parasite involves administration of a composition containing at least one metazoan protease inhibitor in an amount effective to inhibit the protease of the metazoan parasite and thus kill the parasite.</p> |