DNA ENCODING MURINE PRECURSOR INTERLEUKIN 1 beta CONVERTING ENZYME

摘要

Complementary DNA (cDNA) encoding the murine precursor interleukin-1 beta (pre-IL-1 beta ) converting enzyme (ICE) is isolated from a murine cDNA library. A cDNA, encoding the full-length open reading frame (ORF) for the nascent ICE as well as the 20 kDa subunit and the 10 kDa subunit of ICE are identified and sequenced. ICE is useful in the conversion of pre-IL-1 beta into mature IL-1 beta . The murine ICE cDNA is useful in obtaining the genomic sequence. The recombinantly produced murine ICE is useful in the identification of inhibitors of ICE activity.