发明名称 |
METHOD FOR MAKING VALPROIC ACID DERIVATIVES |
摘要 |
A method for making a valproic acid derivative comprising a functionalized spacer arm attached to a (delta) carbon atom of a valproic acid molecule is disclosed. The method proceeds by attaching a spacer arm joined to an inorganic moiety to a valproic acid precursor to make an alkylated compound, derivatizing the alkylated compound in a liquid medium to make the valproic acid derivative, and then separating the valproic acid derivative from the liquid medium. The valproic acid derivative can be used to make an immunoreactive valproic acid conjugate. |
申请公布号 |
WO9406745(A1) |
申请公布日期 |
1994.03.31 |
申请号 |
WO1993US07365 |
申请日期 |
1993.08.05 |
申请人 |
BECKMAN INSTRUMENTS, INC. |
发明人 |
CHENG, ANTHONY, K.;DOBASHI, THOMAS |
分类号 |
C07C51/09;C07C51/347;C07C51/38;C07C55/02;C07C69/34;C07C227/18;C07C229/06;C07C253/30;C07C255/19;C07K16/00;C07K16/44;G01N33/94;(IPC1-7):C07C55/00 |
主分类号 |
C07C51/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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