| 摘要 |
PURPOSE:To let medical material have antigen property against decomposition enzyme when it is embedded in a human body or when it is applied on a traumatic surface, and therein maintain necessary mechanical strength for a specified period of time as well as to allow propagated cells come inside with ease with affinity for cells and tissues maintained excellent by letting carriers be combined with or coated with denatured collagen containing the specified amount of helices. CONSTITUTION:Cell aggressive medical materials are carriers with which denatured collagen containing 0 to 80% helices is combined, or to which the same is applied. Denatured collagen containing 0 to 80% helices can be obtained in such a way that collagen derived from true cow skin is oxidized or alkalized so as to let the obtained collagen including triple chain helices be heated upto 50 to 125 deg.C, preferably 90 to 121 deg.C for 20 minutes to 24 hours under the presence of water. Helix content means triple chain helix content which is characteristic to collagen, in denatured collagen, the aforesaid helices are transformed into the state of random coiling, helix content is therefore corresponds to the degree of denaturation. |
