| 摘要 |
A CM-chitin derivative which has, as an essential unit, a cohesive peptide represented by the following general formula (I), bonded to the side chain of CM-chitin, wherein the bond connecting CM-chitin and said peptide is selected from the group consisting of an amido bond, an ester bond, an ether bond and a urethane bond: -(R1)-(CO)-((X)-Arg-Gly-Asp-(Y))n-(Z)-(R2)- . . . (I)(SEQ ID NO:1) wherein the bracket ( ) means that the corresponding group or residue may be present or absent and if they are present, X and Y each represents an amino acid residue selected from the group consisting of Ser, Gly, Val, Asn and Pro or a peptide residue; Z represents -O- or -NH-; one of R1 and R2 represents a hydrogen atom, or a substituted or unsubstituted alkyl group having 1 to 9 carbon atoms or aryl group having 6 to 9 carbon atoms and the other represents a hydrogen atom, a linear or branched alkylene group having 1 to 9 carbon atoms or an arylene group having 6 to 9 carbon atoms wherein the alkylene and arylene groups may have substituents; and n is an integer ranging from 1 to 5. The derivative or salt thereof is useful as an effective component of compositions for inhibiting adhesion of animal cells or for inhibiting coagulation of blood platelets.
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