| 摘要 |
A process for the preparation of a compound of general formula (* CHEMICAL STRUCTURE *) (III) wherein X represents a cyano group, a group -COOH or a salt, ester or amido derivative thereof, R1 represents a hydrogen atom or an optionally substituted alkyl group, R2 represents an optionally substituted alkyl or phenyl group, Z represents an alkyl group or a halogen atom and n represents 0, 1, 2, 3 or 4, the process comprising reacting a compound of general formula (* CHEMICAL STRUCTURE *) (IV) with a first reactant capable of both dehydrating the amide group of said compound of general formula IV, to form a group X wherein X represents a cyano group, and reacting with the carboxy group of said compound of general formula IV to form a group with which a compound of general formula R1R2NH may react; subsequently reacting the resulting compound with a compound of general formula R1R2NH to form a compound of general formula III wherein X represents a cyano group; and optionally derivatizing that compound to form other compounds of general formula III, is disclosed.
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