发明名称 |
SOLUBLE LOW-DENSITY LIPOPROTEIN RECEPTOR AND ITS PREPARATION |
摘要 |
A truncation of the human LDL receptor gene has been created which can be expressed in a heterologous host to produce a soluble fragment to the receptor protein. The gene can be expressed in insect cells in culture to produce a protein fragment which is not only water soluble but which also retains affinity for binding to LDL. The truncation is a truncation of the carboxyl terminus of the native LDL receptor gene which results in a 354 amino acid protein fragment designated LDL-R-<3><5><4>. |
申请公布号 |
JPH0687895(A) |
申请公布日期 |
1994.03.29 |
申请号 |
JP19930208193 |
申请日期 |
1993.08.02 |
申请人 |
WISCONSIN ALUMNI RES FOUND |
发明人 |
ARAN DEII ATSUTEII;SUTEFUEN ERU SUTAARII;DANIERU JII GURETSUCHI |
分类号 |
A61K38/00;A61P3/06;C07K14/705;C12N15/09;C12N15/12;C12P21/02;C12R1/91;(IPC1-7):C07K13/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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