发明名称 |
THERAPEUTISCHE CHINUCLIDINDERIVATE. |
摘要 |
PCT No. PCT/US89/05338 Sec. 371 Date Jul. 20, 1990 Sec. 102(e) Date Jul. 20, 1990 PCT Filed Nov. 20, 1989 PCT Pub. No. WO90/05729 PCT Pub. Date May 31, 1990.A series of cis-3-[(cyclic)methylamino]-2-[( alpha -substituted)arylmethyl]quinuclidines, 3-[(cyclic)methylimino]-2-[( alpha -substituted)-arylmethyl]quinuclidines and cis-3-[(cyclic)-methyleneamino]-2-[( alpha -substituted)arylmethyl]-quinuclidines, including their pharmaceutically acceptable salts, are disclosed. These particular compounds are found to be useful as substance P antagonists and therefore, are of value in treating gastrointestinal disorders, central nervous system disorders, inflammatory diseases and pain or migraine. Preferred member compounds include cis-3-[(2-chlorophenyl)methylamino]-2-benzhydryl-quinuclidine, cis-3-[(2-trifluorophenyl)methylamino]2-benzhydrylquinuclidine and cis-[(2-methoxyphenyl)methylamino]-2-benzhydrylquinuclidine. Methods for preparing these compounds from known starting materials are provided. |
申请公布号 |
DE68913194(D1) |
申请公布日期 |
1994.03.24 |
申请号 |
DE1989613194 |
申请日期 |
1989.11.20 |
申请人 |
PFIZER, INC., NEW YORK, N.Y., US |
发明人 |
LOWE, JOHN ADAMS III, STONINGTON, CT 06378, US |
分类号 |
A61K31/435;A61K31/44;A61K31/47;A61P1/00;A61P1/04;A61P11/00;A61P25/00;A61P25/04;A61P25/18;A61P25/20;A61P29/00;C07D453/02 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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