Process for producing enyne derivatives

摘要

A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane epoxidase of Eumycetes and strong anti-cholesterol activities. The process comprises reacting a compound of the formula: (* CHEMICAL STRUCTURE *) (IV) wherein W is a halogen atom, with an acetylene derivative, in the presence of a palladium catalyst, to obtain a compound of the formula: (* CHEMICAL STRUCTURE *) (VII) and, if necessary, N-alkylating this compound.