| 摘要 |
The present patent application discloses compounds of the formula <IMAGE> wherein R1 is C1-10 saturated or unsaturated alkyl; or <IMAGE> wherein R''' is H or <IMAGE> R2 is phenyl which is unsubstituted or substituted one or more times with halogen, CF3, C1-6-alkoxy, NO2, CO2-C1-6-alkyl, methyl; benzyl which may be substituted one or more times with halogen, CF3, C1-6-alkoxy, NO2, CO2-C1-6-alkyl, methyl; pyridyl; or cyclohexyl; R3 phenyl which is unsubstituted or substituted one or more times with halogen, CF3, C1-6-alkoxy, NO2, CO2-C1-6-alkyl, methyl; naphthyl which may be substituted one or more times with halogen, CF3, C1-6-alkoxy, NO2, CO2-C1-6-alkyl, methyl; pyridyl; C1-6 unsaturated alkyl; furanyl; R4 is H, C1-6-alkyl, or benzyl; or <IMAGE> together form <IMAGE> <IMAGE> R' and R'' are each hydrogen or together form an extra benzo ring; and wherein the dotted line represents an optional extra bond between the two carbon atoms designated alpha and beta , or a pharmaceutically-acceptable addition salt thereof. The compounds are useful as pharmaceuticals, for example in the treatment of Ca overload in brain cells.
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