| 摘要 |
<p>PURPOSE:To obtain a new long chain alkyl derivative of an amino acid, useful as a synthetic intermediate for surfactants or amphiphatic substances capable of forming an organic thin film or a closed type liposome in water and functioning as an emulsifying agent in a two-component system or water and an oil and having high reactivity. CONSTITUTION:The objective long-chain alkyl derivative of an amino acid is expressed by the formula (X is hydroxymethyl or carboxyl; Y is O constituting an ester or NH constituting an amide; R and R' are 12-18C long-chain alkyl), e.g. N-tetradecanoyl-L-serine-dodecyl ester. This compound expressed by the formula is obtained by reacting serine having protected amino and hydroxyl groups with a long-chain alkylamine or a long-chain alkyl alcohol, then removing the protecting groups, reacting a long-chain fatty acid therewith and finally releasing the protecting group of hydroxyl group. Since this compound expressed by the formula already contains the long-chain alkyl as a hydrophobic group in its structure, hydrophilic residues can be coupled to a chemical substance ranging from a low to a high polymers to simply afford a wide range of functional surfactants and amphiphatic substances.</p> |
