SUSTAINED RELEASE OF OPHTHALMIC DRUGS FROM A SOLUBLE POLYMER DRUG DELIVERY VEHICLE

摘要

A bioerodible drug delivery vehicle with improved flexibility and texture and methods for its use for the controlled administration of a predetermined dosage of at least one pharmaceutical agent for a prolonged period are disclosed and claimed. The vehicle is a generally solid polymeric matrix formed from derivatised cellulose and methacrylic acid copolymer, preferably including a plasticizer and incorporating at least one pharmaceutical agent when placed in a physiological environment such as the cul-de-sac of the eye, the drug delivery vehicle concurrently bioerodes and dispenses the incorporated pharmaceutical agent.