| 摘要 |
The invention features the use of platelet factor 4 (PF4) for inhibiting proliferation of osteoblasts in a mammal in need of such inhibition. The method entails administering PF4. PF4 can be used to treat both diseases characterized by primary changes in osteoblastic cell funtion/activity (e.g., osteosarcoma) and diseases or systemic conditions affecting bone in which abnormal osteoblastic cell function/activity is a secondary effect (e.g., osteoporosis). In addition, PF4 may be used to treat diseases associated with localized changes in bone metabolism in which abnormal osteoblastic cell function/activity contributes to pathogenic bone changes, e.g., periodontal disease, rheumatoid arthritis and osteoarthritis, localized osteoporosis, mastocytosis, multiple myeloma, and bone metastases of various tumors. |
