发明名称 |
INHIBITION OF THE FORMATION OR ACTIVITY OF HUMAN LEUKOCYTE 12-LIPOXYGENASE PATHWAY |
摘要 |
The discovery of a new form of 12-lipoxygenase RNA and protein in human adrenal, mononuclear, vascular smooth muscle and endothelial cells is disclosed. Activation of this 12-LO pathway mediates angiotensin II and glucose induced vascular and renal actions. A rationale for the development of pharmaceutical or molecular methods to inhibit this newly discovered lipoxygenase pathway is described. |
申请公布号 |
WO9405777(A1) |
申请公布日期 |
1994.03.17 |
申请号 |
WO1993US08106 |
申请日期 |
1993.08.26 |
申请人 |
CITY OF HOPE |
发明人 |
NADLER, JERRY, L.;NATARAJAN, RAMA, DEVI;GU, JIALI |
分类号 |
C12N9/04;A61K31/00;A61K31/045;A61K31/05;A61K31/155;A61K31/195;A61K31/20;A61K31/35;A61K31/44;A61K31/575;A61K38/00;A61K38/08;A61K38/44;A61P9/00;C12N9/02;C12N9/99;C12N15/12;G01N33/573;(IPC1-7):C12N9/02;A61K37/24;C07K13/00;C12N1/38 |
主分类号 |
C12N9/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|