LONG WAP PROMOTER FOR MAMMARY EXPRESSION OF HUMAN PROTEIN C

摘要

Recombinant protein C characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate DNAs according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes protein C, such that the DNA is stably incorporated in the DNA of germ line cells of the mature animal and inherited in normal, mendelian fashion. Particularly efficient expression was accomplished using a long whey acidic protein promoter and genomic protein C.