STIMULATION OF AN ANTITUMOR T-CELL RESPONSE USING ANTI-IDIOTYPIC ANTIBODIES

摘要

Anti-idiotypic antibodies containing internal images which mimic tumor associated antigens are useful as vaccines to stimulate a T-cell immune response in a tumor bearing subject or in a subject at risk for malignancy. The antibodies are administered and the T-cell response of the subject is monitored in order to assess the efficacy of the protocols and/or the antibodies are administered in combination with an adjuvant known to enhance T-cell responses.