发明名称 |
AN ANTIVIRALLY ACTIVE PHARMACEUTICAL OIL-IN-WATER EMULSION CONTAINING 9-[(2-HYDROXYETHOXY)METHYL]GUANINE (ACYCLOVIR) OR A SALT OR ESTER THEREOF |
摘要 |
An antivirally active pharmaceutical oil-in-water emulsion containing 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir) or a salt or ester thereof as an active ingredient in the continuous aqueous phase, said phase in addition to said active ingredient and the dispersed oil phase containing a water miscible organic solvent, wherein a polyhydric alcohol may form a constituent. The emulsion comprises from 1 % to 10 % w/w of acyclovir or a salt or ester thereof, from 20 % to 50 % w/w of organic solvent comprising from 5 % to 50 % w/w glycerol formal and from 0 % to 29 % w/w of a polyhydric alcohol, and from 20 % to 40 % w/w water, said percentages being based on the total weight of the formulation. As a polyhydric alcohol propylene glycol may be used, and the emulsion may be available as a cream, wherein the oil phase comprises white vaseline, liquid paraffin (paraffin oil), glycerol monostearate, and stearic acid. |
申请公布号 |
WO9405258(A1) |
申请公布日期 |
1994.03.17 |
申请号 |
WO1993DK00288 |
申请日期 |
1993.09.09 |
申请人 |
A/S GEA FARMACEUTISK FABRIK |
发明人 |
GEBHARD-HANSEN, KNUD, ERIK;PEDERSEN, SOEREN, BOLS;BJOERNSDOTTIR, KAREN;LISSAU, BODIL, GYLLEMBOURG;ALHEDE, BOERGE, INGVAR, FRISCH |
分类号 |
A61K9/107;A61K9/00;A61K9/113;A61K31/52;A61K31/522;A61K47/00;A61K47/06;A61K47/10;A61K47/12;A61K47/14;(IPC1-7):A61K9/107 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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