摘要 |
The invention relates to novel titanocene derivatives possessing chemotherapeutic activity and method for their preparation. These compounds possess two cyclopentadiene rings linked to titanium as a central atom and bound covalently to two phenoxy groups which possess a substituent R selected from the group consisting of: COOCH3, COOC2H5, H, COOCH2CH2OCH2CH2OCH3 and are free from amino groups, nitro, chloride and fluoride. The novel compounds represent a compromise between the main properties for an antitumor agent, i.e. electrophilicity and stability, being water soluble. Cytotoxicity measurements of these compounds showed significant growth inhibition properties, expressed in terms of IC50(M) values. |