| 摘要 |
PURPOSE:To obtain a new compound, excellent in suppressing effects on gastric acid secretion and inhibiting action on proton pumps and useful as an antiulcer agent with hardly any side effects. CONSTITUTION:The objective compound of formula I [R1 is H or (substituted) lower alkyl; R2 is quinolyl, phenyl, etc.; R3 is H or methyl; R4 is triazolyl, pyridino, etc.; X is N, S, etc.; Y is sulfonyl or carbonyl; A is methylene, ethylenethio, etc.; Ph is unsubstituted or methoxy-substituted phenylene], e.g. 2-[N-(2-aminoethyl)-N-(5-isoquinolinesulfonyl)]-amino-N-(4-chlorobenzy l)-N-methyl- benzylamine. This compound is obtained by reacting, e.g. 2-nitrobenzaldehyde with methylamine, providing a compound of formula II, then reacting the resultant compound of formula II with a compound of the formula ClCH2R4, subsequently reducing the produced compound of formula III, successively reacting the prepared compound with a compound of the formula R2SO2Cl and a compound of formula IV (R5 is lower alkyl) and finally reacting the formed product with HCl. |
