| 摘要 |
PURPOSE:To highly sensitively and safely detect a nuclei acid component to be labeled by introducing a specific element to a nuclei acid or nuclei acid mixture in advance. CONSTITUTION:A nuclei acid sample is labeled in advance with an element which is not contained in natural nuclei acids or another element which is contained in natural nuclei acids by an extremely small amount. For example, nucleotide in which the oxygen element at the phosphoric ester bonding part is substituted by sulfur atoms is biochemically bonded in advance with the ends of cut pieces of deoxyribonuclei acid. When a labeled nuclei acid solution in a sample solution tank 1 is transferred to a filler 14 together with an eluent in an eluent tank 15 by means of a liquid pump 2, the cut pieces of nuclei acid successively form segregated zones 16 in order from that having the smallest mass number and the zones 16 move to a labeled element detecting section 9. Therefore, the zones 16 can be continuously detected at the section. |
