Lactide polymers from P4112489 as wound covering or cell culture substrates - as foil or spray wound prepns. which easily be applied, are adsorbable, transparent and able to cover large areas

摘要

Use of co-polymers of racemic lactide (according to patent application P4112489) for the covering of wounds is new. Pref. the co-polymers are used as a spray or a foil. The prepn. additionally may include medically active substances, e.g. antiseptics or antibiotics. Also claimed is the use of the above polymers as carriers for cell cultures. ADVANTAGE - The prepns. as sprays or foil can easily be applied onto wounds since they stick well, large areas can be covered, the cover is adsorbable and are transparent, so that the healing can be observed easily. The claimed polymers are a better substrate for cell cultures than conventional substrates. In an example, racemic lactide and epsilon-caprolactone were mixed in a molar ratio of 85:15 and slowly heated to 150 deg. C. Polymerisation was started by the addn. of 0.04 ml tin II-diethyl hexanoate. After heating in an oil bath (20h, 150 deg. C) and cooling, acetic ester was added to 1l and the mass was shaken for 20h. The resulting soln. can be used as a wound spray either with or without antibiotics.