发明名称 |
Tetracyclines alone or in combination with NSAID for treating tissue destruction. |
摘要 |
<p>A method for treating mammals suffering from rheumatoid arthritis, other tissue-destructive conditions, and chronic inflammatory or other conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of a non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss. <IMAGE></p> |
申请公布号 |
EP0586020(A1) |
申请公布日期 |
1994.03.09 |
申请号 |
EP19930202588 |
申请日期 |
1993.09.03 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
GOLUB, LORNE M.;RAMAMURTHY, NANGAVARUM S.;MCNAMARA, THOMAS F.;GREENWALD, ROBERT A. |
分类号 |
A61K31/19;A61K31/195;A61K31/40;A61K31/405;A61K31/54;A61K31/60;A61K31/65;A61K45/00;A61P29/00;A61P43/00;(IPC1-7):A61K31/65 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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