| 摘要 |
PURPOSE:To obtain a compound useful e.g. as an intermediate for 1beta- methylcarbapenems for antibacterial agent, etc., in high yield and stereoselectivity at a low cost by reacting a specific beta-lactam derivative with a pyrrolidin-2-one compound and hydrolyzing the reaction product. CONSTITUTION:The objective beta-lactam derivative expressed by formula IV and useful as an intermediate for 1beta-methylcarbapenems for antibacterial agent can be produced in high yield and stereoselectivity at a low cost by reacting a beta-lactam derivative expressed by formula I (R<1> is H or OH-protecting group; Y is eliminable group) [e.g. (l'R,3R,4R)-3-(1'-t-butyldimethylsiloxyethyl)-4- acetoxyazetidin-2--one] with a pyrrolidin-2-one derivative expressed by formula II (R<2> is lower alkyl; X is halogen) [e.g. 1-(2-bromopropionyl)-5,5- dimethylpyrrolidin-2-one] to obtain a beta-lactam derivative of formula III and hydrolyzing the derivative. |
