Substituted imidazole derivatives and their preparation and use

摘要

Compounds of the formula: (* CHEMICAL STRUCTURE *) (I) wherein X is -CH2- or (* CHEMICAL STRUCTURE *) R1 is H, C1-5-alkyl or benzyl, which can be substituted or unsubstituted R2 is H, C1-4-alkyl, OH or C1-3-alkoxy R3 is H, CH3, CH2CH3, OCH3 or Hal R4 is H, CH3, CH2CH3, OCH3 or Hal and Hal is halogen and non-toxic acid addition salts and mixtures thereof are highly selective antagonists at postsynaptic (alpha)2-adrenoceptors, and are especially useful in the treatment of diabetes.