发明名称 |
Stabilization of active plasminogen activator inhibitor-1 |
摘要 |
Processes for stabilizing active PAI-1 protein comprising combining active PAI-1 protein with an aqueous buffer having an ionic strength of at least about 5 millisiemens and a sugar selected from the group consisting of monosaccharides and disaccharides, and/or subjecting the active PAI-1 protein to lyophilization, are disclosed. Also described are compositions, including pharmaceutical compositions and kits, which include the stabilized active PAI-1 protein, and therapeutic processes employing the same in the treatment of fibrinolysis.
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申请公布号 |
US5290764(A) |
申请公布日期 |
1994.03.01 |
申请号 |
US19920820523 |
申请日期 |
1992.01.14 |
申请人 |
THE DUPONT MERCK PHARMACEUTICAL COMPANY |
发明人 |
DUKE, JR., JODIE L.;WALTON, JR., HARRY L.;REILLY, THOMAS M. |
分类号 |
A61K38/57;(IPC1-7):A61K37/00;A61K35/14 |
主分类号 |
A61K38/57 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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