Facile condensation of methylbenzoxazoles with aromatic aldehydes

摘要

An efficient process for the preparation of styrylbenzoxazoles and derivatives thereof comprises reacting a methylbenzoxazole with an aromatic aldehyde in the presence of strong base at low temperature, followed by warming. The condensation products are inhibitors of H+K+-ATPase, and are also useful as penultimate compounds in the preparation of inhibitors of HIV reverse transcriptase.