METHODS FOR PRODUCING CYCLOPEPTIDES PROMOTING ABSORPTION OF PEPTIDES AND ALBUMINS THROUGH MUCOUS MEMBRANE AS WELL AS PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS AS AUXILIARY AGENTS

摘要

The invention relates to the compounds of the general formula I and to the physiologically tolerated salts thereof, in which X is a basic L- or D-amino acid, Y is a neutral or basic L- or D-amino acid, Z is a neutral or basic L- or D-amino acid which can be identical to or different from Y, R<1> is an N-bonded acyl radical of the formula II in which Ar is a phenyl radical which is optionally substituted by 1, 2 or 3 identical or different radicals from the series comprising hydroxyl, (C1-C4)-alkoxy, amino, carboxyl, (C1-C4)-alkylamino and halogen, or is a 2-aminothiazol-4-yl radical, p is an integer from zero to 4 and q, n, m and l are, independently of one another, zero or 1. The invention additionally relates to the use of compounds of the formula I and their physiologically tolerated salts for promoting the absorption of peptides and proteins on administration onto the mucous membrane and to pharmaceutical compositions which contain a pharmacologically effective amount of one or more peptides or proteins as well as a compound of the formula I or its physiologically tolerated salts.