Synthetic HIV-1 protease peptides of amino acids 45-55, 90-99 and 60-70 - either inhibiting or stimulating HIV reverse transcriptase; useful in treatment of HIV-1 or SIV infections
摘要
A synthetic peptide substantially including amino acids 45-55, 90-99 or 60-70 of the HIV-1-protease sequence is claimed. Also claimed is an agent for the treatment of HIV or SIV infections comprising a HIV protease not showing protease activity (PR) for HIV1-reverse transcriptase (RT) but stimulating or inhibiting it. More specifically the active centre of the protease is destroyed by mutation or deletion, or the deriv. is a protease shortened at the C- terminus by 2 amino acids. USE/ADVANTAGE - The agents are used for the treatment of HIV or SIV infections. Compared to known treatment using e.g. nucleotide analogues, the new peptides do not interfere with normal cell function.
申请公布号
DE4225925(A1)
申请公布日期
1994.02.24
申请号
DE19924225925
申请日期
1992.08.05
申请人
DEUTSCHES PRIMATENZENTRUM GMBH, 3400 GOETTINGEN, DE