2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides

摘要

Novel compounds which are 2,6-methano-2H-1-benzoxocincarboxamides having 5-HT3-antagonist properties including unique CNS, antiemetic and gastric prokinetic activities and which are void of any significant D2 receptor binding affinity, therapeutic compositions and methods of treatment of disorders which result from 5-HT3 activity using said compounds. Processes for their preparation and the preparation of their intermediates are also disclosed.