| 摘要 |
The present invention provides a method for treating osteoporosis in a mammal comprising administering to said mammal a therapeutically-effective amount of a 2-, 3-, 8- and/or 10-substituted dibenzoxazepine compound having a structure of the formula: (* CHEMICAL STRUCTURE *) or a pharmaceutically-acceptable salt thereof, wherein: X is -NH- or -CH2-; Y is (1) -CH2- when X is -NH-, and (2) -NH- when X is -CH2-; R1 is hydrogen, halogen or -OR4; R4 is hydrogen, alkyl or (* CHEMICAL STRUCTURE *) Z is oxygen, sulfur, -SO-, -SO2- or -NR5-; R5 is hydrogen or t-butyloxycarbonyl; R2 is hydrogen, halogen or trifluoromethyl; R3 is hydrogen, halogen, aryl, heteroaryl in which the heteroatoms are selected from oxygen, nitrogen and/or sulfur, or -NR6R7; R6 and R7 are each independently hydrogen or alkyl; R8 is alkyl, aryl or (* CHEMICAL STRUCTURE *) R9 and R10 are each independently hydrogen or alkyl, or when taken together form N-morpholino or 4-methyl-N-piperazinyl; m and n are each independently integers of from 0 to 3; and P is 0 or 1, provided that p is not 1 when m is 0.
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