ENDOTHELIN RECEPTOR-BINDING COMPOUNDS

摘要

Compounds of the formula (I): XN-X1-X2-X3-X4-X5-X6-XC are useful as agonists and antagonists of endothelin, where XN is acyl or other N-terminal group, or a polypeptide of 1-50 amino acids; XC is OH or other C-terminal group, or a polypeptide of 1-50 amino acids; and X1-X3 are each independently a peptide or peptoid, and X4-X6 are each independently a peptide, peptoid, or a bond, and at least one of X1-X5 is selected from the group consisting of Nglu, Naeg, Nphe, Nile, Nlys, Nleu, Nmet, Nasn, Ngln, Narg, Nhser, Nthr, Nhtrp, Nhtyr, Norn, Nbhm, Nbhe, Nnbhm, Nnbhe, and Nbmc.